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The FRAT® Experience
Neurodiversity & Wellbeing

The FRAT® Experience

Discover the science behind FRAT®—a groundbreaking test linking folate autoantibodies to autism, NTDs, CFD, and more, guiding effective folinic acid therapy.

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Autism
Autism

Bedwetting And Autism: Understanding The Connection And Possible Folate Link

Discover the link between bedwetting and autism. Find out how folate and vitamin B12 deficiencies might be connected to this issue. Learn about potential causes, treatment options, and how to support your child.

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Neurodiversity & Wellbeing Vitamin B9, It’s importance and relevance in Autism
Neurodiversity & Wellbeing

Vitamin B9, It’s importance and relevance in Autism

Discover the essential role of Vitamin B9 in autism, including the impact of folate receptor autoantibodies and promising treatments with high-dose folinic acid.

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Developmental Origins of Health and Disease (DOHaD) Neonatal Microbiome Breastfed Infants Versus Formula Fed Infants
Developmental Origins of Health and Disease (DOHaD)

Developmental Origins of Health and Disease: Infant Gut Microbiome ~ Day 31 to 364

Explore the human microbiome’s impact on health, focusing on infant gut development, feeding modes, antibiotics, and the benefits of probiotics and prebiotics.

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Neurodiversity & Wellbeing Autism and Older Fathers – Is there a connection?
Neurodiversity & Wellbeing

Autism and Older Fathers – Is there a connection?

Explore the connection between older fathers and autism risk. Learn about genetic mutations, epigenetic changes, and environmental factors contributing to this link.

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Autism What Can Cause Autism?
Autism

What Can Cause Autism?

Genetic, Environmental, Energy Metabolism, Neurological, Immunological, Nutritional, and Folate: Explore the Potential Causes of Autism Spectrum Disorder.

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Neurodiversity & Wellbeing Autism and Mitochondria
Neurodiversity & Wellbeing

Autism and Mitochondria

Explore the link between mitochondria and autism spectrum disorder (ASD), including their role in energy metabolism, oxidative stress, genetics, and cognitive development.

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Developmental Origins of Health and Disease (DOHaD) Gut Microbiota - Newborns
Developmental Origins of Health and Disease (DOHaD)

Developmental Origins of Health and Disease: Neonatal Gut Microbiome ~ Day 0 to 30

Discover how the neonatal gut microbiome develops from day 0 to 30, shaping immune health and long-term wellness through environmental factors and maternal influences.

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Neurodiversity & Wellbeing Folate, Autism and Cerebral Folate Deficiency Syndrome
Neurodiversity & Wellbeing

Folate, Autism and Cerebral Folate Deficiency Syndrome

Cerebral Folate Deficiency Syndrome (CFDS), linked to autism, affects brain development due to low CSF folate levels. Learn more about symptoms, causes, and treatment options.

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Autism Understanding Autism in Girls vs Boys
Autism

Understanding Autism in Girls vs Boys

Learn why girls with autism are often underdiagnosed and explore the unique challenges they face. This blog explores the gender gap in autism diagnosis and the importance of recognizing diverse presentations.

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Neurodiversity & Wellbeing How Does Having a Child With Autism Affect Parenting?
Neurodiversity & Wellbeing

How Does Having a Child With Autism Affect Parenting?

Parenting a child with autism can be challenging and rewarding. Discover practical tips and guidance on understanding, support systems, therapy, communication, and more.

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Folate and Vitamin B12 (In Health and Disease) Folate Interconversions and Degradation
Folate and Vitamin B12 (In Health and Disease)

Folate in Health and Disease: Determination of Folate Vitamers in Serum, Whole Blood, and Cerebrospinal Fluid

Explore advanced methods for determining folate vitamers in serum, whole blood, and cerebrospinal fluid. Learn more about folate stability, interconversions, and accurate measurement techniques.

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Neurodiversity & Wellbeing Cerebral Folate Deficiency Syndrome – The Latest News
Neurodiversity & Wellbeing

Cerebral Folate Deficiency Syndrome – the latest News

Learn more about Cerebral Folate Deficiency Syndrome (CFDS) its symptoms, causes, diagnosis, and effective treatments to manage this neurological disorder.

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Autism Why ABA Therapy Doesn’t Work?
Autism

Why ABA Therapy Doesn’t Work?

Discover why ABA therapy might not work for everyone, exploring known limitations and emerging factors like cerebral folate deficiency affecting autism treatment.

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Neurodiversity & Wellbeing Making Friends with an Autistic Child
Neurodiversity & Wellbeing

Making Friends with an Autistic Child

Learn how parents can help their children befriend autistic children, fostering understanding and inclusivity in school-age friendships.

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Developmental Origins of Health and Disease (DOHaD) Epigenetic Remodeling in Embryogenesis
Developmental Origins of Health and Disease (DOHaD)

Developmental Origins of Health and Disease: Epigenetics, Nutrition, and Infant Health

Explore how epigenetics and nutrition impact infant health and development, influencing lifelong well-being through mechanisms like DNA methylation and histone modification.

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  • FRAT® (Folate Receptor Antibody Test) is a diagnostic blood test that screens for Folate Receptor Autoantibodies. Developed in the laboratory of Dr. Edward Quadros at the State University of New York (SUNY Downstate), FRAT® is the only assay that identifies BOTH blocking and binding Folate Receptor Autoantibodies. FRAT®, as published in the New England Journal of Medicine, and used in numerous clinical trials, is the world's leading assay of its kind.

    The presence of Folate Receptor Autoantibodies suggests that folate (vitamin B9), which is an essential vitamin for proper growth and neurological function, is not being properly transported to the brain and into the cerebrospinal fluid (CSF).

    Folate Receptor Autoantibodies have been found in Cerebral Folate Deficiency Syndrome, Autism Spectrum Disorders, Depression, Schizophrenia as well as other neuropsychiatric and neurodevelopmental disorders.

    Diagnosis of Folate Receptor Autoantibodies should be done as early as possible as this may affect treatment outcomes.

    Please consult your physician for further information.

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