The Mitochondrial Power Plant -Why Vitamin B9 (Folate) is Your Cells’ Secret Energy Booster
Learn how Vitamin B9 (folate) supports mitochondrial function, cellular energy, DNA synthesis, brain health, and overall wellness with this complete guide.
FRAT® and Autism
Autism in the United States has surged and continues to grow at an alarming rate. The CDC reports that 1 in 36 children have been identified with autism spectrum disorder (ASD). Folate Receptor Autoantibodies have been found to be highly prevalent in children with ASD. The folate receptor alpha (FRa) is responsible for actively transporting folate into several body organs including the fetus and brain. Folate Receptor Autoantibodies interfere with the ability of the FRa to function properly, thereby affecting folate transport. This condition may be treated with alternate reduced folates. Early diagnosis can lead to earlier intervention and possibly greater improvement. Please consult your physician for more information.
What is FRAT® ?
FRAT® is a vital blood test that screens for Folate Receptor Autoantibodies, which hinder the proper transport of essential folate (vitamin B9) to the brain and Cerebrospinal Fluid (CSF). This deficiency can contribute to Cerebral Folate Deficiency Syndrome, among other neurodevelopmental and neuropsychiatric disorders.
Why FRAT® test in Autism?
A large percentage of children with Autism have been found to have Folate Receptor Autoantibodies. FRAT® will confirm the presence of these autoantibodies, which suggests that not enough folate (vitamin B9) is being transported into the brain.
Why do FRAT® right now?
Don't wait to take action! Early diagnosis is the key to optimal treatment outcomes. With the information provided by FRAT®, you and your physician can explore alternate reduced folate treatments that can make a real difference!
What to do after FRAT® ?
Insufficient folate can often be corrected with alternate folate metabolites that bypass the autoantibodies. Consult your physician for further information on available therapeutic approaches.
Lives Tranformed by FRAT®
"What does a central nervous system deprived of a key nutrient look like? In my case, it looked like bipolar disorder, psychosis, and a personality disorder. This presentation led to heavy-handed and wildly ineffective treatments. Fortunately, I found integrative clinicians like Dr. Mary and Dr. Steve Rondeau at the Wholeness Center. They saw my failure to respond to standard care as a clue that something benign might actually soothe my nervous system and reduce my aggressive, bipolar, and psychotic behaviors.
By running a FRAT® test, we discovered that my brain and body were unable to absorb folate-a B9 vitamin. Years of my life were spent on toxic treatments without symptom remission. With the right diagnostics, we found objective data showing what was beneath my neuropsychiatric symptoms. This restored my health and dignity.
The FRAT® test revealed a positive folate receptor autoantibody that inhibited folate binding at the receptor site, in addition to a homozygous MTHFR mutation. With deeper diagnostic testing, we could finally correct the course of treatment and provide a form of folate that crossed the blood-brain barrier to feed my hungry CNS.
I wish every clinician treating patients with mood and behavioral symptoms would screen for this antibody to ensure humane, dignified, and effective treatment."
CELESTE BRINKERHOFF
“FRAT® changed the course of my daughter’s life and our family’s. A simple blood test led our physician on the right path for treatment and today she is thriving! As a parent, you can’t ask for anything more. This would not have happened if we didn’t use FRAT® to screen for folate receptor autoantibodies. We are forever grateful!”
DEANNA H.
“Having a child with ASD is challenging. Even more challenging is navigating what programs, treatments, therapies, and diets will help them improve; this was overwhelming for us at first. We are so thankful for our knowledgeable doctor and for the FRAT® test because our child has improved in so many facets – his speech, his socialization, his attention span – it has been remarkable. Thank you, again.”
MAXWELL M.
Autism Awareness
The Cerebral Folate Highway: Understanding The Barriers To Vitamin B9 Transport Into The Brain
Learn how cerebral folate deficiency occurs when vitamin B9 transport into the brain is disrupted by genetic mutations, autoantibodies, and mitochondrial dysfunction.
Mechanisms of Folate Transport to the Brain – A Fascinating Journey!
Folate transport into the brain explained: FRα, PCFT, and RFC pathways, their role in brain health, and links to cerebral folate deficiency.
The Three Faces of Folate: A Story of Carbon, Genes, and the Chemistry of You
Compare folic acid, folinic acid, and methylfolate (5-MTHF). Learn how MTHFR genetics, methylation, and one-carbon metabolism affect your health.
Sudden Surge in Autism Rates Across the World – A Review of Theories
Explore the global rise in autism rates and key theories including diagnosis changes, genetics, environment, screening, and neurodevelopment research.
Blocking vs. Binding Folate Receptor Autoantibodies
Learn how blocking and binding folate receptor autoantibodies differ in mechanism, diagnosis, and treatment in cerebral folate deficiency.
Why the Folate Receptor Autoantibody Test (FRAT®) is a Game-Changing Biomarker
Learn how the FRAT® test identifies folate receptor autoantibodies linked to cerebral folate deficiency, autism, and neuropsychiatric disorders.