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  • Autism (66)
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  • FRAT (1)
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    • Autism Spectrum Disorders – I (Neurotypical Brain versus Autistic Brain) (8)
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Suicide & Depression: The Silent Epidemic We Must Confront
Autism Spectrum Disorders – II (Comorbid Mental Health Problems)

Suicide & Depression: The Silent Epidemic We Must Confront

Explore the silent epidemic of suicide & depression—its causes, societal impact, and proven prevention strategies that can help save lives.

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Autism Spectrum Disorders – II (Comorbid Mental Health Problems) Suicide & Depression: The Silent Epidemic We Must Confront
Autism Spectrum Disorders – II (Comorbid Mental Health Problems)

Suicide & Depression: The Silent Epidemic We Must Confront

Explore the silent epidemic of suicide & depression—its causes, societal impact, and proven prevention strategies that can help save lives.

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Neurodiversity & Wellbeing Folate. Autism. Depression What’s the Link?
Neurodiversity & Wellbeing

Folate. Autism. Depression What’s the Link?

Explore how folate impacts brain health and its link to depression and autism, including MTHFR mutations, FRAAs, and potential treatment strategies.

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Neurodiversity & Wellbeing Empirical use of Folinic Acid-Why Not Use!
Neurodiversity & Wellbeing

Empirical use of Folinic Acid-Why Not Use!

Discover why high-dose folinic acid should be reserved for FRAT®-positive cases and the importance of FRAT® testing in guiding safe, targeted therapy.

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Mitochondria (In Health and Disease) Proton Power: Life’s Molecular Drive for Energy
Mitochondria (In Health and Disease)

Proton Power: Life’s Molecular Drive for Energy

Explore how proton gradients power life’s energy, from ATP synthesis to cellular transport—unraveling the elegant science behind bioenergetics.

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Neurodiversity & Wellbeing Why is Folinic Acid so Promising in a Subtype of Children with Autism?
Neurodiversity & Wellbeing

Why is Folinic Acid so Promising in a Subtype of Children with Autism?

Discover how folinic acid helps children with autism and FRAAs by restoring brain folate, improving speech, behavior, and communication.

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Neurodiversity & Wellbeing Importance of the Early Detection of FRAAs
Neurodiversity & Wellbeing

Importance of the Early Detection of FRAAs

Early detection of folate receptor autoantibodies (FRAAs) can prevent neurodevelopmental disorders like ASD and CFD. Learn why early testing matters.

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Mitochondria (In Health and Disease) ATP ~ The Molecular Currency that Keeps Life Running - Structure of ATP Molecule
Mitochondria (In Health and Disease)

ATP: The Molecular Currency That Keeps Life Running

ATP is the engine of life—understand its discovery, structure, and function in powering cells through respiration, fermentation, and photosynthesis.

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Neurodiversity & Wellbeing The Connection Between FRAAs, FRAT® and Folinic Acid
Neurodiversity & Wellbeing

The Connection Between FRAAs, FRAT® and Folinic Acid

Discover how FRAAs, the FRAT® test, and folinic acid offer targeted hope for ASD, PANS/PANDAS, and more through folate transport correction.

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Neurodiversity & Wellbeing The History of the FRAT® Test
Neurodiversity & Wellbeing

The History of the FRAT® Test

Discover the FRAT® test—an advanced diagnostic for folate receptor autoantibodies linked to autism, NTDs, and neurodevelopmental disorders.

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Neurodiversity & Wellbeing Why you need the FRAT® test
Neurodiversity & Wellbeing

Why You Need the FRAT® Test?

Discover why the FRAT® test is crucial for detecting folate receptor autoantibodies linked to autism, CFD, and neurological symptoms.

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Mitochondria (In Health and Disease) Cellular Respiration - The Hidden Engine Driving Life's Energy
Mitochondria (In Health and Disease)

Cellular Respiration: The Hidden Engine Driving Life’s Energy

Explore the hidden engine of life—cellular respiration. Discover how glucose, oxygen, and the mitochondrial respiratory chain power every cell through a fascinating journey of energy transformation.

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Neurodiversity & Wellbeing How Folate Receptor Autoantibodies Disrupt Folate Transport at the BBB?
Neurodiversity & Wellbeing

How Folate Receptor Autoantibodies Disrupt Folate Transport at the BBB?

Learn how folate receptor autoantibodies (FRAAs) block folate transport at the BBB, causing cerebral folate deficiency despite normal blood folate levels.

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Neurodiversity & Wellbeing Maternal Autoantibodies and Autism Spectrum Disorders
Neurodiversity & Wellbeing

Maternal autoantibodies and Autism Spectrum Disorders

Discover how maternal autoantibodies may impact fetal brain development and increase autism risk. Learn more about MAR-ASD, key proteins, and emerging research.

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Autism Autism and Down Syndrome: Addressing Common Questions and Misconceptions
Autism

Autism and Down Syndrome: Addressing Common Questions and Misconceptions

Discover key differences and similarities between Autism & Down Syndrome, their causes, symptoms, and co-occurrence.

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Neurodiversity & Wellbeing Autism and Folinic Acid – A New Report by CBS Evening News
Neurodiversity & Wellbeing

Autism and Folinic Acid – A New Report by CBS Evening News

Discover how leucovorin, a folate-based drug, may help speech delays in autism. Learn about research, clinical trials, and parental advocacy for repurposed therapies.

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  • FRAT® (Folate Receptor Antibody Test) is a diagnostic blood test that screens for Folate Receptor Autoantibodies. Developed in the laboratory of Dr. Edward Quadros at the State University of New York (SUNY Downstate), FRAT® is the only assay that identifies BOTH blocking and binding Folate Receptor Autoantibodies. FRAT®, as published in the New England Journal of Medicine, and used in numerous clinical trials, is the world's leading assay of its kind.

    The presence of Folate Receptor Autoantibodies suggests that folate (vitamin B9), which is an essential vitamin for proper growth and neurological function, is not being properly transported to the brain and into the cerebrospinal fluid (CSF).

    Folate Receptor Autoantibodies have been found in Cerebral Folate Deficiency Syndrome, Autism Spectrum Disorders, Depression, Schizophrenia as well as other neuropsychiatric and neurodevelopmental disorders.

    Diagnosis of Folate Receptor Autoantibodies should be done as early as possible as this may affect treatment outcomes.

    Please consult your physician for further information.

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