Positive FRAT® Test: Steps to Take Now!

If you receive a positive result in a folate receptor autoantibody (FRAT^®) test, it’s important to take steps to better understand what it means for your health or the health of your child (if applicable). Let’s discuss a possible road map after receiving FRAT^® results.

As with any medical diagnostic or therapeutic, a physician’s guidance is required. Your medical professional will be able to educate and guide you through the process.

• Neurologist, Developmental Pediatrician, Pediatrician, or DO: If the test is related to your child, especially if they have autism or developmental concerns, consult a developmental pediatrician or neurologist who has experience with FRA autoantibodies. Oftentimes, this will be the physician that authorized and ordered the FRAT^® test.
• Immunologist: An immunologist can help interpret the results and guide next steps regarding immune-related issues.

• Positive FRA Autoantibodies: These are often associated with disruptions in folate transport to the brain and body, potentially leading to conditions like cerebral folate deficiency (CFD), autism spectrum disorders or other neurodevelopmental, neuropsychiatric disorders.
• Severity: Your doctor will help determine the clinical significance, as treatment may correlate with antibody titers. Intervention based on positive results will depend on your physician’s recommendation. It may include the additional of an alternate reduced folate such as folinic acid, or certain dietary adjustments, or both.

• FRA autoantibodies may block folate transport, so doctors often recommend high-dose folinic acid (a bioavailable form of folate) to bypass this issue.
• Work closely with your doctor to determine the appropriate type and dosage of folate supplementation. This generally varies from case to case, as not all individuals are the same, nor do they respond to treatment alike.

• If the test is related to your child, monitor for symptoms that might suggest folate deficiency or CFD, such as:
  • Developmental delays
  • Neurological symptoms (e.g., seizures, ataxia)
  • Gastrointestinal issues
  • Behavioral changes or regression
• Adults may experience fatigue, neurological symptoms, mood alterations, or other signs of folate deficiency.

• Some people may benefit from the elimination of dairy, or animal milks. There is evidence that folate receptor autoantibody titers often fluctuate based on the exposure to dairy. Eliminating dairy in the diet may improve symptoms. Additionally, alternate folate supplementation is usually required in the case of FRA autoantibodies.

• Cerebrospinal Fluid (CSF) Folate Levels: In cases where cerebral folate deficiency is suspected, your doctor may recommend measuring folate levels in the CSF to confirm the diagnosis.
• MTHFR Gene Testing: Since FRA autoantibodies and MTHFR mutations can coexist, genetic testing might provide additional insights into folate metabolism.

• Regular follow-ups with your healthcare provider are essential to monitor progress, adjust treatment, and address any concerns that arise.

• Learn about FRA autoantibodies and their implications. Reputable resources include medical journals, autism-related foundations, and organizations like the National Institutes of Health (NIH). Additional information may also be found on www.fratnow.com

Again, as a reminder, please consult your physician for more information and guidance!