{"id":6794,"date":"2025-06-28T13:00:51","date_gmt":"2025-06-28T13:00:51","guid":{"rendered":"https:\/\/autism.fratnow.com\/blog\/?p=6794"},"modified":"2025-06-28T08:22:21","modified_gmt":"2025-06-28T08:22:21","slug":"the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy","status":"publish","type":"post","link":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/","title":{"rendered":"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy"},"content":{"rendered":"<p>[vc_row][vc_column][vc_single_image image=&#8221;6797&#8243; img_size=&#8221;full&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;Introduction&#8221;][vc_column_text single_style=&#8221;&#8221;]<a href=\"https:\/\/autism.fratnow.com\/blog\/importance-of-vitamin-b9-folate-for-better-brain-development-in-fetuses\/\" target=\"_blank\" rel=\"noopener\">Folate (vitamin B9)<\/a> is essential for DNA synthesis, cell division, and proper fetal development during pregnancy. Maternal folate deficiency is associated with severe complications, including <a href=\"https:\/\/autism.fratnow.com\/blog\/folate-folate-receptor-autoantibodies-neural-tube-defects\/\" target=\"_blank\" rel=\"noopener\">neural tube defects (NTDs)<\/a>, miscarriage, preeclampsia, and other developmental disorders. While folate supplementation is widely recommended, some women still experience folate deficiency-related complications despite adequate intake. Emerging research suggests that\u00a0<strong>folate receptor autoantibodies (FR\u03b1-Ab)<\/strong>\u00a0may impair folate transport to the fetus, leading to functional folate deficiency even when blood levels appear normal.[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]<\/p>\n<p>Detecting\u00a0<strong>folate receptor autoantibodies (FR\u03b1-Ab)<\/strong>\u00a0in pregnancy is crucial because these antibodies can block or disrupt folate uptake, increasing the risk of adverse pregnancy outcomes. Folate receptor autoantibodies may be detected via the FRAT<sup>\u00ae<\/sup> test, which screens for both blocking and binding Fraas. Although not well known, or extensively studied, folate receptor autoantibodies clearly have a role in the mechanisms of pregnancy. There are distinct clinical implications, and the importance of early detection and management of FR\u03b1-Ab in pregnant women cannot be stressed enough.<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text single_style=&#8221;&#8221;]Let\u2019s begin analyzing this connection:<br \/>\n[\/vc_column_text][vc_custom_heading text=&#8221;Understanding Folate Receptor Alpha and Folate Receptor Autoantibodies (FR\u03b1-Ab)&#8221;][vc_column_text single_style=&#8221;&#8221;]Folate receptor alpha (FR\u03b1) is a high-affinity cell receptor responsible for folate (vitamin B9) uptake, particularly in the placenta, brain, and developing fetus.\u00a0This means that folate receptor alpha is a major receptor that readily brings Vitamin B9 (otherwise known as folate) into the cell. This is critical during pregnancy as at this specific time period\/cycle there is extensive cell replication and proper folate transport is critical.[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]<strong>Autoantibodies against FR\u03b1 (FR\u03b1-Ab)<\/strong>, also known as folate receptor autoantibodies, however, can have a detrimental effect on folate receptor alpha when they are present. In essence, they block folate from being properly absorbed into the cells that critically need it. This blockage can have significant negative consequences in the placenta, and in the fetus as well, where folate receptor alpha is readily expressed. In other words, these cells may potentially be starved of proper folate (vitamin B9).[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]Distinctly, there are two types of folate receptor autoantibodies:<\/p>\n<ul class=\"mr-left-ol-40-list mr-left-ul-40\">\n<li><strong>Blocking antibodies<\/strong>\u00a0\u2013 Prevent folate binding to the receptor.<\/li>\n<li><strong>Binding antibodies<\/strong>\u00a0\u2013 Attach to FR\u03b1 but may not fully block folate uptake, though they can still impair transport.<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]Folate receptor autoantibodies can develop due to genetic predisposition, environmental triggers (e.g., infections, dietary factors), or molecular mimicry (where the immune system mistakenly attacks FR\u03b1).<br \/>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;How Do FRaas Affect Pregnancy?&#8221;][vc_column_text single_style=&#8221;&#8221;]<strong>Placental folate transport disruption<\/strong>\u00a0\u2013 FR\u03b1 is highly expressed in the placenta to supply folate to the fetus. Autoantibodies can reduce folate transfer, leading to fetal folate deficiency despite normal maternal serum folate levels. This is an important caveat \u2013 folate levels in the blood may seem normal. However, that may not be the same for folate in the cerebrospinal fluid, thereby creating a neurological folate deficiency. FRAT<sup>\u00ae<\/sup> will detect the presence of folate receptor autoantibodies in these cases.[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]<strong>Neural tube defects (NTDs)<\/strong>\u00a0\u2013 Historically, studies have shown a strong association between Fraas and NTDs (e.g., spina bifida, anencephaly).<br \/>\n[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]<strong>Miscarriage and pregnancy loss<\/strong>\u00a0\u2013 Folate is critical for early embryonic development, and impaired transport increases miscarriage risk. If one has had a prior miscarriage, it may be prudent to test for folate receptor autoantibodies via FRAT<sup>\u00ae<\/sup>.<br \/>\n[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]<strong>Preeclampsia and intrauterine growth restriction (IUGR)\u00a0<\/strong>\u2013 Folate deficiency contributes to endothelial dysfunction and poor placental perfusion.<br \/>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;Why Detecting Fraas in Pregnancy Is Critical&#8221;][vc_column_text single_style=&#8221;&#8221;]Keeping in mind that folate receptor autoantibodies can potentially disrupt folate transport, it is important to identify them as soon as possible. This is especially critical for those that may have high risk pregnancies, or have had miscarriages prior.<br \/>\n[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]Not all women with folate deficiency respond to standard supplementation. Testing for Fraas can help identify those at risk of\u00a0<strong>functional folate deficiency<\/strong>, allowing for targeted interventions.<br \/>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;Preventing Neural Tube Defects (NTDs)&#8221;][vc_column_text single_style=&#8221;&#8221;]In a past study, it was determined that p to 70% of NTD cases may be linked to FRAAs (study by\u00a0<em>Rothenberg et al., 2004<\/em>). Although more studies are necessary, this provides for a good indication on how folate receptor autoantibodies affect pregnancy.[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]Even with folic acid supplementation, women with FR\u03b1-Ab may still have insufficient folate reaching the fetus.<br \/>\n[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]Overall, folate plays such an important role in pregnancy \u2013 from the time of conception and until post-delivery. Folate deficiency is linked to endothelial dysfunction and oxidative stress as seen in preeclampsia. Additionally, inadequate folate affects placental and fetal growth that may relate to preterm birth &amp; low birth weight.<br \/>\n[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]Although much more research is necessary and needs to be undertaken in this specific area, there is some thought that <strong><a href=\"https:\/\/autism.fratnow.com\/blog\/a-comprehensive-introduction-to-autism-spectrum-disorder\/\" target=\"_blank\" rel=\"noopener\">autism spectrum disorder (ASD)<\/a> &amp; neurodevelopmental delays<\/strong> are related to possible folate deficiency and the presences of folate receptor autoantibodies during pregnancy. Folate is critical for brain development; impaired transport may increase ASD risk (<em>Ramaekers et al.<\/em>,)[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;Clinical Evidence Supporting FRAAs Testing&#8221;][vc_column_text single_style=&#8221;&#8221;]This has become a very popular research area as continued discoveries may aid in the reduction of ASD. Some of the key research findings that are of great interest are:<\/p>\n<ul class=\"mr-left-ol-40-list mr-left-ul-40\">\n<li><strong>Rothenberg et al. (2004)<\/strong>\u00a0\u2013 Found FR\u03b1-Ab in\u00a0<strong>75% of mothers with NTD-affected pregnancies<\/strong>\u00a0vs. 10% controls.<\/li>\n<li><strong>Ramaekers et al. (2007, 2013)<\/strong>\u00a0\u2013 Linked FR\u03b1-Ab to cerebral folate deficiency (CFD) and autism.<\/li>\n<li><strong>Molloy et al. (2009)<\/strong>\u00a0\u2013 Showed FR\u03b1-Ab reduces folate uptake in placental cells.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;Current Screening Recommendations&#8221;][vc_column_text single_style=&#8221;&#8221;]While not yet routine, testing with FRAT<sup>\u00ae<\/sup> may be recommended for:<\/p>\n<ul class=\"mr-left-ol-40-list mr-left-ul-40\">\n<li>Women with a history of\u00a0<strong>NTD-affected pregnancies.<\/strong><\/li>\n<li>Unexplained\u00a0<strong>recurrent miscarriages.<\/strong><\/li>\n<li><strong>Autism or developmental delays<\/strong>\u00a0in previous children.<\/li>\n<li><strong>Low serum folate but normal dietary intake.<\/strong><\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text single_style=&#8221;&#8221;]As mentioned in the above, FRAT<sup>\u00ae<\/sup> is not a routine practice in the field of pregnancy. Please consult your medical professional for further information and guidance. More research is needed to define clinically significant antibody levels, but this is a good start. [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;Potential for Early Intervention&#8221;][vc_column_text single_style=&#8221;&#8221;]Preconception screening\u00a0may help in identifying FRAAs before pregnancy and can potentially allow for early folate optimization. This is an area that needs to be pursued![\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;Conclusion&#8221;][vc_column_text single_style=&#8221;&#8221;]Detecting\u00a0<strong><a href=\"https:\/\/autism.fratnow.com\/blog\/folate-receptor-autoantibodies-in-families-with-autistic-individuals\/\" target=\"_blank\" rel=\"noopener\">folate receptor autoantibodies (FRaas)<\/a><\/strong>\u00a0in pregnancy is a critical yet underutilized strategy to prevent\u00a0<strong>neural tube defects, miscarriage, preeclampsia, and neurodevelopmental disorders<\/strong>. Since standard folic acid may not be sufficient in FRAAs &#8211; positive women, early identification allows for\u00a0<strong>personalized folate<\/strong>, possibly improving pregnancy outcomes.\u00a0FRAAs testing via FRAT<sup>\u00ae<\/sup> should be incorporated into prenatal care for high-risk women, particularly those with a history of NTDs, recurrent pregnancy loss, or unexplained folate deficiency. Further research and clinical guidelines are needed to optimize detection and treatment protocols. As with any medical issue, please consult your physician for further information.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;References&#8221;][vc_column_text single_style=&#8221;&#8221;]<\/p>\n<ul class=\"mr-left-ol-40\">\n<li>Rothenberg SP, et al. (2004). Autoantibodies against folate receptors in women with a pregnancy complicated by a neural tube defect.\u00a0<em>N Engl J Med<\/em>.<\/li>\n<li>Ramaekers VT, et al. (2013). Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism.\u00a0<em>Mol Psychiatry.<\/em><\/li>\n<li>Molloy AM, et al. (2009). Maternal folate status and the risk of neural tube defects.\u00a0<em>Lancet.<\/em><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Detecting folate receptor autoantibodies (FR\u03b1-Ab) in pregnancy is key to preventing NTDs, miscarriage, and complications despite normal folate levels.<\/p>\n","protected":false},"author":4,"featured_media":6797,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy<\/title>\n<meta name=\"description\" content=\"Detecting folate receptor autoantibodies (FR\u03b1-Ab) in pregnancy is key to preventing NTDs, miscarriage, and complications despite normal folate levels.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy\" \/>\n<meta property=\"og:description\" content=\"Detecting folate receptor autoantibodies (FR\u03b1-Ab) in pregnancy is key to preventing NTDs, miscarriage, and complications despite normal folate levels.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/\" \/>\n<meta property=\"og:site_name\" content=\"fratnow.com\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/autismfrat\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-28T13:00:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-28T08:22:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2025\/06\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy-blog-listing-image.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"730\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Steve Tsetsekos\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy\" \/>\n<meta name=\"twitter:description\" content=\"Detecting folate receptor autoantibodies (FR\u03b1-Ab) in pregnancy is key to preventing NTDs, miscarriage, and complications despite normal folate levels.\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2025\/06\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy-blog-listing-image.webp\" \/>\n<meta name=\"twitter:creator\" content=\"@AutismFrat\" \/>\n<meta name=\"twitter:site\" content=\"@AutismFrat\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Steve Tsetsekos\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"Article\",\"BlogPosting\"],\"@id\":\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/\"},\"author\":{\"name\":\"Steve Tsetsekos\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/d5e4020455f25cb3768f5eb9ad5e9f1c\"},\"headline\":\"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy\",\"datePublished\":\"2025-06-28T13:00:51+00:00\",\"dateModified\":\"2025-06-28T08:22:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/\"},\"wordCount\":1450,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#organization\"},\"articleSection\":[\"Neurodiversity &amp; Wellbeing\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/\",\"name\":\"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy\",\"isPartOf\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#website\"},\"datePublished\":\"2025-06-28T13:00:51+00:00\",\"dateModified\":\"2025-06-28T08:22:21+00:00\",\"description\":\"Detecting folate receptor autoantibodies (FR\u03b1-Ab) in pregnancy is key to preventing NTDs, miscarriage, and complications despite normal folate levels.\",\"breadcrumb\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/autism.fratnow.com\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#website\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/\",\"name\":\"fratnow.com\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/autism.fratnow.com\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#organization\",\"name\":\"fratnow.com\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/08\/logo.png\",\"contentUrl\":\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/08\/logo.png\",\"width\":194,\"height\":66,\"caption\":\"fratnow.com\"},\"image\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/autismfrat\",\"https:\/\/twitter.com\/AutismFrat\",\"https:\/\/www.linkedin.com\/company\/88011685\/admin\/\",\"https:\/\/www.instagram.com\/fratautism\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/d5e4020455f25cb3768f5eb9ad5e9f1c\",\"name\":\"Steve Tsetsekos\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/09\/e6cec733-36d3-42ae-a0a7-986995164499_medium.jpg\",\"contentUrl\":\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/09\/e6cec733-36d3-42ae-a0a7-986995164499_medium.jpg\",\"caption\":\"Steve Tsetsekos\"},\"sameAs\":[\"https:\/\/autism.fratnow.com\/blog\/\"],\"url\":\"https:\/\/autism.fratnow.com\/blog\/author\/steve-tsetsekos\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy","description":"Detecting folate receptor autoantibodies (FR\u03b1-Ab) in pregnancy is key to preventing NTDs, miscarriage, and complications despite normal folate levels.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/","og_locale":"en_US","og_type":"article","og_title":"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy","og_description":"Detecting folate receptor autoantibodies (FR\u03b1-Ab) in pregnancy is key to preventing NTDs, miscarriage, and complications despite normal folate levels.","og_url":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/","og_site_name":"fratnow.com","article_publisher":"https:\/\/www.facebook.com\/autismfrat","article_published_time":"2025-06-28T13:00:51+00:00","article_modified_time":"2025-06-28T08:22:21+00:00","og_image":[{"width":730,"height":400,"url":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2025\/06\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy-blog-listing-image.webp","type":"image\/webp"}],"author":"Steve Tsetsekos","twitter_card":"summary_large_image","twitter_title":"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy","twitter_description":"Detecting folate receptor autoantibodies (FR\u03b1-Ab) in pregnancy is key to preventing NTDs, miscarriage, and complications despite normal folate levels.","twitter_image":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2025\/06\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy-blog-listing-image.webp","twitter_creator":"@AutismFrat","twitter_site":"@AutismFrat","twitter_misc":{"Written by":"Steve Tsetsekos","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["Article","BlogPosting"],"@id":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/#article","isPartOf":{"@id":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/"},"author":{"name":"Steve Tsetsekos","@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/d5e4020455f25cb3768f5eb9ad5e9f1c"},"headline":"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy","datePublished":"2025-06-28T13:00:51+00:00","dateModified":"2025-06-28T08:22:21+00:00","mainEntityOfPage":{"@id":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/"},"wordCount":1450,"commentCount":0,"publisher":{"@id":"https:\/\/autism.fratnow.com\/blog\/#organization"},"articleSection":["Neurodiversity &amp; Wellbeing"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/","url":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/","name":"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy","isPartOf":{"@id":"https:\/\/autism.fratnow.com\/blog\/#website"},"datePublished":"2025-06-28T13:00:51+00:00","dateModified":"2025-06-28T08:22:21+00:00","description":"Detecting folate receptor autoantibodies (FR\u03b1-Ab) in pregnancy is key to preventing NTDs, miscarriage, and complications despite normal folate levels.","breadcrumb":{"@id":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/autism.fratnow.com\/blog\/the-importance-of-detecting-folate-receptor-autoantibodies-in-pregnancy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/autism.fratnow.com\/blog\/"},{"@type":"ListItem","position":2,"name":"The Importance of Detecting Folate Receptor Autoantibodies in Pregnancy"}]},{"@type":"WebSite","@id":"https:\/\/autism.fratnow.com\/blog\/#website","url":"https:\/\/autism.fratnow.com\/blog\/","name":"fratnow.com","description":"","publisher":{"@id":"https:\/\/autism.fratnow.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/autism.fratnow.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/autism.fratnow.com\/blog\/#organization","name":"fratnow.com","url":"https:\/\/autism.fratnow.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/08\/logo.png","contentUrl":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/08\/logo.png","width":194,"height":66,"caption":"fratnow.com"},"image":{"@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/autismfrat","https:\/\/twitter.com\/AutismFrat","https:\/\/www.linkedin.com\/company\/88011685\/admin\/","https:\/\/www.instagram.com\/fratautism\/"]},{"@type":"Person","@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/d5e4020455f25cb3768f5eb9ad5e9f1c","name":"Steve Tsetsekos","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/09\/e6cec733-36d3-42ae-a0a7-986995164499_medium.jpg","contentUrl":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/09\/e6cec733-36d3-42ae-a0a7-986995164499_medium.jpg","caption":"Steve Tsetsekos"},"sameAs":["https:\/\/autism.fratnow.com\/blog\/"],"url":"https:\/\/autism.fratnow.com\/blog\/author\/steve-tsetsekos\/"}]}},"_links":{"self":[{"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/posts\/6794"}],"collection":[{"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/comments?post=6794"}],"version-history":[{"count":3,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/posts\/6794\/revisions"}],"predecessor-version":[{"id":6799,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/posts\/6794\/revisions\/6799"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/media\/6797"}],"wp:attachment":[{"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/media?parent=6794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/categories?post=6794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/tags?post=6794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}