Table of Contents<\/b><\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_single_image image=”6153″ img_size=”full”][vc_column_text single_style=””]<\/p>\n Figure 1. The schematic shows that diversity increases from day 0 to day 1,000 of life.<\/strong> The development of the gut microbiome from infancy to childhood is indeed a fascinating and complex process. Birth mode<\/em><\/strong>, initial feeds<\/em><\/strong>, and weaning<\/em><\/strong> are major events in which the diversity increases more rapidly.<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row el_id=”introduction”][vc_column][vc_custom_heading text=”Introduction”][vc_column_text single_style=””]<\/p>\n Neonatal and, to a lesser degree, infant gut microbiome development is chaotic, dynamic<\/strong>, and highly individual.<\/strong> As discussed in our previous blogs, the temporal development of the bacterial community during this time can be influenced significantly by environmental, host-related<\/strong>, and clinical variables<\/strong>. By 1 to 3 years of age there is generally less clinical intervention, and the gut microbiome reaches a \u201cclimax community\u201d<\/em><\/strong> of microbes that will generally remain stable through adulthood (see Figure 1<\/strong>) [1-3]. (Cf. previous blogs entitled as: \u2018Developmental Origins of Health and Disease: Neonatal Gut Microbiome ~ Day 0 to 30.<\/u><\/a>\u2019; and \u2018Developmental Origins of Health and Disease: Infant Gut Microbiome ~ Day 31 to 364.\u2019<\/u><\/a>)<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text single_style=””]<\/p>\n Although there is no specific gut microbiome in adults, compared to neonates and infants there is a notable increase in the Bacteroidetes at the expense of Proteobacteria, while Firmicutes remains relatively dominant from birth. The more adultlike gut microbiome is predominantly characterized by increased abundances of the following genera:<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text single_style=””]<\/p>\n The exact age at which the adult-like community is established is not yet known and likely varies between individuals, especially driven by nutritional status<\/strong> and geography<\/strong>, with Western populations reaching maturation by 1 year of life<\/span>.<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text single_style=””]<\/p>\n In a study comparing the gut microbiome of children aged 0 to 3 years between three extreme groups \u2013 (i) American Indians from the Amazon<\/strong>, (ii) Rural Malawians<\/strong>, and (iii) urban American<\/strong> – the bacterial profiles were distinct between the groups, but the Western American children were the greatest outliers [4]. Notably, Bifidobacteria<\/em> still dominated the communities from all locations.<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text single_style=””]<\/p>\n Although the gut microbiome is still developing, there are many factors contributing to the microbes that colonize it. Aside from the geographical<\/em><\/strong> and dietary<\/em><\/strong> extremes earlier, more subtle influences within a given population may have profound long-term effects. Having siblings results in a higher proportion of Bifidobacterium compared to single infants<\/em><\/strong> [5].<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text single_style=””]<\/p>\n Perhaps unsurprisingly, the gut microbiomes of twins are more comparable to each other than those of other nonrelated infants<\/span>, but it is unclear if this is driven by comparable environmental exposure of genetic influence<\/em><\/strong>. Exposure to animals, such as household pets<\/em><\/strong>, will also shape the developing gut microbiome.<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_single_image image=”6154″ img_size=”full”][vc_column_text single_style=””]<\/p>\n Figure 2. Role of gut microbiota in nutrition and health.<\/strong> Schematic representation of the role of the gut microbiota in health and disease giving some examples of inputs and outputs: (i)<\/strong> Gut microbiota influences many areas of human health from innate immunity to appetite and energy metabolism;<\/em><\/strong> (ii)<\/strong> Targeting the gut microbiome with probiotics or dietary fiber<\/em><\/strong>, benefits human health and could potentially reduce obesity; (iii)<\/strong> Drugs, food ingredients, antibiotics, and pesticides<\/em><\/strong> could all have adverse effects on the gut microbiota; (iv)<\/strong> Microbiota should be considered a key aspect in nutrition<\/em><\/strong> \u2013 the medical community should adapt their education and public health messages; (v)<\/strong> Fiber consumption<\/em><\/strong> is associated with beneficial effects in several contexts. [CVD, cardiovascular disease; LPS, lipopolysaccharide] (Adapted and modified from: Valdes AM, Walter J, Segal E, Spector TD. Role of the gut microbiota in nutrition and health. BMJ. 2018 Jun 13;361:k2179.<\/em> Doi: https:\/\/doi.org\/10.1136\/bmj.k2179<\/a><\/u>) [6].<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text single_style=””]<\/p>\n A recent study showed that the gut microbiome profiles of preterm infants<\/strong> at 1 to 3 years of age was comparable to that of term infants in terms<\/strong> of both diversity and the abundant bacterial genera<\/span> [7]. The same study also found no profound lasting effects on the gut microbiome (a) from a previous diagnosis of disease, (b) number of days of antibiotics, (c) gestational age, (d) birth mode, and (e) mode of delivery.<\/p>\n [\/vc_column_text][vc_column_text single_style=””]<\/p>\n These findings are further supported by a recent study, which found that the same variables do not influence the gut microbiome long term, with the additional findings that maternal weight also has no lasting effect<\/em><\/strong>.<\/p>\n [\/vc_column_text][vc_column_text single_style=””]<\/p>\n There is currently a progressive increase in metabolic and immune-mediated diseases in infants and children for which the developing gut microbiome might have important consequences<\/u><\/span> (see Figure 2<\/strong>). Studies exploring the gut microbiome in allergic disease<\/em><\/strong> and obesity<\/em><\/strong> have risen in recent years, but the direct effect of the gut microbiome on these conditions is not well determined. Still, it is reasonable to postulate that the gut microbiome will have important influences.<\/p>\n [\/vc_column_text][vc_column_text single_style=””]<\/p>\n For example, a reduced abundance of Bacteroides<\/em>, which is common to the Western diet associated with low dietary fiber intake, was shown to predict atopic eczema<\/em><\/strong> (see Figure 2<\/strong>). Likewise for obesity, a reduced abundance of Bifidobacterium<\/em> and an increased prevalence of Staphylococcus<\/em> was found at 1 year of age in infants who went on to become obese<\/em><\/strong> at 7 years of age.<\/p>\n [\/vc_column_text][vc_column_text single_style=””]<\/p>\n The neonatal and infant phases seem the most applicable for modulation of the gut microbiome. However, in certain circumstances, such as following antibiotic administration<\/em><\/strong>, there may be clear rationale for seeding a beneficial gut microbiome through the use of probiotics and prebiotics<\/em><\/strong>.<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=”blog-text-35795″ el_id=”blog-scroll-point-8″][vc_column][vc_custom_heading text=”Take Home Messages” el_class=”blog-text-35795″][vc_column_text single_style=””]Introduction<\/em><\/strong><\/p>\n [\/vc_column_text][vc_column_text single_style=””]Adult-like gut microbiome<\/em><\/strong><\/p>\n [\/vc_column_text][vc_column_text single_style=””]Influencing factors<\/em><\/strong><\/p>\n [\/vc_column_text][vc_column_text single_style=””]<\/p>\n Health implications<\/em><\/strong><\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=”blog-text-35795″ el_id=”conclusion”][vc_column][vc_custom_heading text=”Summary and Conclusions” el_class=”blog-text-35795″][vc_column_text single_style=””]<\/p>\n Although microbiome research has offered unprecedented information on the role of microbes in health and disease, the field as a whole is still emerging. Further work is needed to ascertain the extent to which microbiome findings are causative and the subsequent mechanism, proving causality over existing correlations. The next decades offers huge promise for microbiome research, no more so than for the developing infant, where the first 1,000 days offers a key window to establish a beneficial population contributable to long-term health.<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text single_style=”” el_class=”blog-banner-section”]<\/p>\n Folate (vitamin B9) is very important for your child\u2019s brain development!<\/p>\n During pregnancy, it helps prevent neural tube defects and plays a big role in forming a normal and healthy baby\u2019s brain and spinal cord. Folate also helps cells divide and assists in both DNA and RNA synthesis.<\/p>\n Emerging research suggests that the presence of FRAAs negatively impacts folate transport into the brain.<\/p>\n Yes, there is a test – The Folate Receptor Antibody Test (FRAT\u00ae<\/sup>) has emerged as a diagnostic tool for detecting the presence of FRAAs.<\/p>\n It is important to screen at an early age or as soon as possible as there may be corrective measures available. Please consult your physician for further information.<\/p>\n To request a test kit, click on the button below.<\/p>\n Request Now<\/a><\/p>\n<\/div>\n<\/div>\n [\/vc_column_text][vc_column_text single_style=”” el_class=”text-gray-23″]For information on autism monitoring, screening and testing please read our blog<\/a>.[\/vc_column_text][\/vc_column][\/vc_row][vc_row el_id=”blog-references” el_class=”blog-text-35795″][vc_column][vc_custom_heading text=”References” use_theme_fonts=”yes”][vc_column_text single_style=”” el_id=”blog-ref-3564″]<\/p>\n [\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":" Explore the transition from infant to child gut microbiome, its stabilization, key influencing factors, and its impact on long-term health in the first 1,000 days.<\/p>\n","protected":false},"author":3,"featured_media":6152,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76,77,64],"tags":[],"yoast_head":"\n\n
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\n\u200b<\/li>\n\n
Did You Know? Folate Receptor Autoantibodies (FRAAs) may impede proper folate transport.<\/h4>\n
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Is there a test for identifying Folate Receptor Autoantibodies (FRAAs)?<\/h4>\n
![\"FRAT](\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/12\/frat-mascot-image.webp\")
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\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/30529020\/<\/a><\/li>\n
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/29118049\/<\/a><\/li>\n
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/28826938\/<\/a><\/li>\n
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/22699611\/
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\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/16882802\/<\/a><\/li>\n
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/29899036\/<\/a><\/li>\n
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/26598071\/
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