{"id":5661,"date":"2024-03-02T11:53:11","date_gmt":"2024-03-02T11:53:11","guid":{"rendered":"https:\/\/autism.fratnow.com\/blog\/?p=5661"},"modified":"2024-03-02T12:00:19","modified_gmt":"2024-03-02T12:00:19","slug":"folate-fras-frat-subfertility-autism-reproductive-health","status":"publish","type":"post","link":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/","title":{"rendered":"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?"},"content":{"rendered":"

[vc_row][vc_column][vc_single_image image=”5662″ img_size=”full”][\/vc_column][\/vc_row][vc_row el_id=”introduction”][vc_column][vc_custom_heading text=”Folate, FRAAs, FRAT\u00ae<\/sup> and Subfertility”][vc_column_text single_style=””]<\/p>\n

It is well known that Folate supplementation reduces the risk of neural tube defects (NTD) in pregnancy<\/a>. Folate, also known as vitamin B9, is crucial at the moment of conception for several reasons. It plays a vital role in the early development of the neural tube, which later forms the baby’s brain and spinal cord. Sufficient folate intake before and during early pregnancy can significantly reduce the risk of neural tube defects. Folate is also necessary for the synthesis and repair of DNA, as well as for cell division. During conception and early pregnancy, when cells are rapidly multiplying and differentiating, folate is essential for the proper development of the embryo.<\/p>\n

[\/vc_column_text][vc_column_text single_style=””]<\/p>\n

Folate crosses into cells using two main transporter mechanisms. Folate Receptor \u03b1(FR\u03b1) is the main transporter and mediated transport is the primary mechanism due to its high affinity for folate. Using this mechanism, folate binds to the FR\u03b1 on the apical side of the cell and the receptor undergoes endocytosis and is transported to the basal side of the cell. This process is an active transport mechanism that requires ATP. The Reduced Folate Carrier (RFC) acts as an alternate system to transport folate. However, it is important to note that the RFC is not as efficient at transporting folate as the FR\u03b1 mechanism primarily due to lower affinity for folate compared with the FR\u03b1.<\/p>\n

[\/vc_column_text][vc_column_text single_style=””]<\/p>\n

In the absence of systemic folate deficiency, the discovery of autoantibodies to FR\u03b1 that block the uptake of folate offers one possible mechanism to explain the response to folate in certain neurological disorders such as cerebral folate deficiency and autism spectrum disorders. The association of folate receptor autoantibodies<\/a> with pregnancy-related complications including CFD syndrome and autism spectrum disorders, and with the response to folate therapy (folinic acid), is highly suggestive of the involvement of these autoantibodies in the disruption of proper function of the folate pathway.<\/p>\n

[\/vc_column_text][vc_column_text single_style=””]<\/p>\n

Folate is important for the proper functioning of reproductive tissues, including the ovaries. It is normally transported to the ovaries via the folate receptor (FR\u03b1), and in one study targeting women with difficulties in conceiving, approximately thirty percent (30%) had folate receptor autoantibodies [1]. This study and its respective findings demonstrating the presence of folate receptor autoantibodies in these women offers a plausible explanation for their subfertility. Given that this was a small study, additional studies are warranted. Blockage of the folate receptor alpha by folate receptor autoantibodies during the periconception period could alter proper folate bioavailability during the early stages of cell division and embryogenesis. This hypothesis seems to have considerable merit and certainly warrants further investigation.<\/p>\n

[\/vc_column_text][vc_column_text single_style=””]<\/p>\n

Paternal folate deficiency is a less studied subject. The association of paternal folate status to reproduction has largely been limited to sperm quality. Folate, as the initial substrate in one-carbon metabolism, is converted into 5-methyltetrahydrofolate in liver prior to distribution to various tissues. Subsequently, 5-methyltetrahydrofolate catalyzed by methionine synthase with vitamin B12 as cofactor provides homocysteine with a methyl group to form methionine and S-adenosyl-methionine (SAM), the universal methyl donor required for methylation of DNA, RNA,<\/b> proteins, and lipids and their methylation maintenance. Moreover, 5-methyltetrahydrofolate catalyzed by methylenetetrahydrofolate reductase (MTHFR<\/i>) generates tetrahydrofolate and 5,10- methylenetetrahydrofolate, which are used for purine and thymidylate biosynthesis, respectively [2],[3].<\/p>\n

[\/vc_column_text][vc_column_text single_style=””]<\/p>\n

Despite the essential functions of biosynthesis and methylation, the majority of studies have focused on the role of the folate<\/a> in the normal reproductive function of women. Thus far, the role of folate in male reproduction, particularly spermatogenesis and spermatogenesis-related gene expression, has been rarely investigated. The folate pathway is so important, and inhibited folate transport which may develop due to the presence of folate receptor autoantibodies, may explain some causes of sub-fertility. Again, it may be prudent to investigate if folate receptor autoantibodies are present in the male as well.<\/p>\n

[\/vc_column_text][vc_column_text single_style=””]<\/p>\n

Additionally, it has also been hypothesized that paternal folate deficiency influences placental folate transfer, and in turn, may result in unfavorable fetal outcomes similar to that of maternal folate deficiency [4]. With this is mind, screening for folate receptor autoantibodies in males may be warranted.<\/p>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”FRAT\u00ae<\/sup>“][vc_column_text single_style=””]<\/p>\n

FRAT\u00ae<\/sup> (Folate Receptor Antibody Test) was developed to determine the presence of folate receptor autoantibodies in serum. The two types of autoantibodies identified by FRAT\u00ae<\/sup> in the serum of patients are blocking antibodies and binding antibodies. The autoantibodies measured by specific assays, and their pathological effects are described as:<\/p>\n

    \n
  1. Blocking Autoantibodies; the functional blocking of folate transport at the receptor level.<\/li>\n
  2. Binding Autoantibodies; by disrupting the Folate Receptor alpha via an antigen-antibody-mediated functional deficit and an inflammatory response.<\/li>\n<\/ol>\n

    [\/vc_column_text][vc_column_text single_style=””]<\/p>\n

    These autoantibodies could exert their effect, either by blocking folate transport or potentially by an antibody-mediated immune reaction. In the absence of gross fetal abnormalities, exposure to these autoantibodies during fetal development or in early infancy could disrupt the structural refinement of the brain and cause functional deficits in later life (i.e. Autism). These observations further attest to the importance of folate status during early brain development and to the identification of factors that could disrupt this essential need.<\/p>\n

    [\/vc_column_text][vc_column_text single_style=””]<\/p>\n

    Because folate receptor autoantibodies are associated with various pathologies during fetal and neonatal development and early brain development, timely detection and intervention could prevent or reverse the consequences of exposure to these antibodies. In such cases, it is advised to consult a physician.<\/p>\n

    [\/vc_column_text][\/vc_column][\/vc_row][vc_row el_id=”ref-section”][vc_column][vc_custom_heading text=”Reference”][vc_column_text single_style=””]<\/p>\n

    \n
      \n
    1. Berrocal-Zaragoza MI, Fernandez-Ballart JD, Murphy MM, Cavall\u00e9-Busquets P, Sequeira JM, Quadros EV.<\/a> Association between blocking folate receptor autoantibodies and subfertility.<\/b> Fertil Steril.<\/a> 2009 Apr;91(4 Suppl):1518-21.
      \ndoi: 10.1016\/j.fertnstert.2008.08.104. Epub 2008 Oct 23.<\/li>\n
    2. Hong-Fang Yuan, Kai Zhao, Yu Zang, Chun-Yan Liu, Zhi-Yong Hu, Jia-Jing Wei, Ting Zhou, Ying Li and Hui-Ping Zhang. Effect of folate deficiency on promoter methylation and gene expression of Esr1, Cav1, and Elavl1,<\/i> and its influence on spermatogenesis.<\/b> Oncotarget, 2017 Vol.8 (No. 18) pp:24130-24141<\/li>\n
    3. R. Lambrot, C. Xu1, S. Saint-Phar, G. Chountalos, T. Cohen, M. Paquet, M. Suderman, M. Hallett & S Kimmins. Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes.<\/b> Nature Communications, Published 10. Dec 2013; DOI: 10.1038\/ncomms3889<\/li>\n
    4. Hye Won Kim, Yun Jung Choi, Ki Nam Kim, Tsunenobu Tamura and Namsoo Chang. Effect of paternal folate deficiency on placental folate content and folate receptor \u03b1 expression in rats.<\/b> Nutrition Research and Practice (Nutr Res Pract) 2011;5(2):112-116 DOI: 10.4162\/nrp.2011.5.2.112<\/li>\n<\/ol>\n<\/div>\n

      [\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"

      Discover the connection between folate, FRAT\u00ae<\/sup>, and subfertility. Explore the impact of FRAAs on reproduction & neurodevelopment.<\/p>\n","protected":false},"author":4,"featured_media":5662,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"yoast_head":"\nWhat is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?<\/title>\n<meta name=\"description\" content=\"Discover the connection between folate, FRAT\u00ae, and subfertility. Explore the impact of folate receptor autoantibodies on reproduction and neurodevelopment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?\" \/>\n<meta property=\"og:description\" content=\"Discover the connection between folate, FRAT\u00ae, and subfertility. Explore the impact of folate receptor autoantibodies on reproduction and neurodevelopment.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/\" \/>\n<meta property=\"og:site_name\" content=\"fratnow.com\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/autismfrat\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-02T11:53:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-02T12:00:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2024\/03\/what-is-the-link-between-folate-subfertility-brain-development-asd-and-fraas-blog-banner-image.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"730\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Steve Tsetsekos\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?\" \/>\n<meta name=\"twitter:description\" content=\"Discover the connection between folate, FRAT\u00ae, and subfertility. Explore the impact of folate receptor autoantibodies on reproduction and neurodevelopment.\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2024\/03\/what-is-the-link-between-folate-subfertility-brain-development-asd-and-fraas-blog-banner-image.webp\" \/>\n<meta name=\"twitter:creator\" content=\"@AutismFrat\" \/>\n<meta name=\"twitter:site\" content=\"@AutismFrat\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Steve Tsetsekos\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"Article\",\"BlogPosting\"],\"@id\":\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/\"},\"author\":{\"name\":\"Steve Tsetsekos\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/d5e4020455f25cb3768f5eb9ad5e9f1c\"},\"headline\":\"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?\",\"datePublished\":\"2024-03-02T11:53:11+00:00\",\"dateModified\":\"2024-03-02T12:00:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/\"},\"wordCount\":1186,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#organization\"},\"articleSection\":[\"Neurodiversity & Wellbeing\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/\",\"name\":\"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?\",\"isPartOf\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#website\"},\"datePublished\":\"2024-03-02T11:53:11+00:00\",\"dateModified\":\"2024-03-02T12:00:19+00:00\",\"description\":\"Discover the connection between folate, FRAT\u00ae, and subfertility. Explore the impact of folate receptor autoantibodies on reproduction and neurodevelopment.\",\"breadcrumb\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/autism.fratnow.com\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#website\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/\",\"name\":\"fratnow.com\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/autism.fratnow.com\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#organization\",\"name\":\"fratnow.com\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/08\/logo.png\",\"contentUrl\":\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/08\/logo.png\",\"width\":194,\"height\":66,\"caption\":\"fratnow.com\"},\"image\":{\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/autismfrat\",\"https:\/\/twitter.com\/AutismFrat\",\"https:\/\/www.linkedin.com\/company\/88011685\/admin\/\",\"https:\/\/www.instagram.com\/fratautism\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/d5e4020455f25cb3768f5eb9ad5e9f1c\",\"name\":\"Steve Tsetsekos\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/09\/e6cec733-36d3-42ae-a0a7-986995164499_medium.jpg\",\"contentUrl\":\"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/09\/e6cec733-36d3-42ae-a0a7-986995164499_medium.jpg\",\"caption\":\"Steve Tsetsekos\"},\"sameAs\":[\"https:\/\/autism.fratnow.com\/blog\/\"],\"url\":\"https:\/\/autism.fratnow.com\/blog\/author\/steve-tsetsekos\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?","description":"Discover the connection between folate, FRAT\u00ae, and subfertility. Explore the impact of folate receptor autoantibodies on reproduction and neurodevelopment.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/","og_locale":"en_US","og_type":"article","og_title":"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?","og_description":"Discover the connection between folate, FRAT\u00ae, and subfertility. Explore the impact of folate receptor autoantibodies on reproduction and neurodevelopment.","og_url":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/","og_site_name":"fratnow.com","article_publisher":"https:\/\/www.facebook.com\/autismfrat","article_published_time":"2024-03-02T11:53:11+00:00","article_modified_time":"2024-03-02T12:00:19+00:00","og_image":[{"width":730,"height":400,"url":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2024\/03\/what-is-the-link-between-folate-subfertility-brain-development-asd-and-fraas-blog-banner-image.webp","type":"image\/webp"}],"author":"Steve Tsetsekos","twitter_card":"summary_large_image","twitter_title":"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?","twitter_description":"Discover the connection between folate, FRAT\u00ae, and subfertility. Explore the impact of folate receptor autoantibodies on reproduction and neurodevelopment.","twitter_image":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2024\/03\/what-is-the-link-between-folate-subfertility-brain-development-asd-and-fraas-blog-banner-image.webp","twitter_creator":"@AutismFrat","twitter_site":"@AutismFrat","twitter_misc":{"Written by":"Steve Tsetsekos","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["Article","BlogPosting"],"@id":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/#article","isPartOf":{"@id":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/"},"author":{"name":"Steve Tsetsekos","@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/d5e4020455f25cb3768f5eb9ad5e9f1c"},"headline":"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?","datePublished":"2024-03-02T11:53:11+00:00","dateModified":"2024-03-02T12:00:19+00:00","mainEntityOfPage":{"@id":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/"},"wordCount":1186,"commentCount":0,"publisher":{"@id":"https:\/\/autism.fratnow.com\/blog\/#organization"},"articleSection":["Neurodiversity & Wellbeing"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/","url":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/","name":"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?","isPartOf":{"@id":"https:\/\/autism.fratnow.com\/blog\/#website"},"datePublished":"2024-03-02T11:53:11+00:00","dateModified":"2024-03-02T12:00:19+00:00","description":"Discover the connection between folate, FRAT\u00ae, and subfertility. Explore the impact of folate receptor autoantibodies on reproduction and neurodevelopment.","breadcrumb":{"@id":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/autism.fratnow.com\/blog\/folate-fras-frat-subfertility-autism-reproductive-health\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/autism.fratnow.com\/blog\/"},{"@type":"ListItem","position":2,"name":"What is the link between Folate, Subfertility, Brain Development, ASD and FRAAs?"}]},{"@type":"WebSite","@id":"https:\/\/autism.fratnow.com\/blog\/#website","url":"https:\/\/autism.fratnow.com\/blog\/","name":"fratnow.com","description":"","publisher":{"@id":"https:\/\/autism.fratnow.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/autism.fratnow.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/autism.fratnow.com\/blog\/#organization","name":"fratnow.com","url":"https:\/\/autism.fratnow.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/08\/logo.png","contentUrl":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/08\/logo.png","width":194,"height":66,"caption":"fratnow.com"},"image":{"@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/autismfrat","https:\/\/twitter.com\/AutismFrat","https:\/\/www.linkedin.com\/company\/88011685\/admin\/","https:\/\/www.instagram.com\/fratautism\/"]},{"@type":"Person","@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/d5e4020455f25cb3768f5eb9ad5e9f1c","name":"Steve Tsetsekos","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/autism.fratnow.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/09\/e6cec733-36d3-42ae-a0a7-986995164499_medium.jpg","contentUrl":"https:\/\/autism.fratnow.com\/blog\/wp-content\/uploads\/2023\/09\/e6cec733-36d3-42ae-a0a7-986995164499_medium.jpg","caption":"Steve Tsetsekos"},"sameAs":["https:\/\/autism.fratnow.com\/blog\/"],"url":"https:\/\/autism.fratnow.com\/blog\/author\/steve-tsetsekos\/"}]}},"_links":{"self":[{"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/posts\/5661"}],"collection":[{"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/comments?post=5661"}],"version-history":[{"count":2,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/posts\/5661\/revisions"}],"predecessor-version":[{"id":5664,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/posts\/5661\/revisions\/5664"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/media\/5662"}],"wp:attachment":[{"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/media?parent=5661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/categories?post=5661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/autism.fratnow.com\/blog\/wp-json\/wp\/v2\/tags?post=5661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}